Detecting “different”: Pyrin senses modified GTPases

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome

RAS GTPases are modified by SUMOylation

RAS proteins are GTPases that participate in multiple signal cascades, regulating crucial cellular processes including cell survival, proliferation, differentiation, and autophagy. Mutations or deregulated activities of RAS are frequently the driving force for oncogenic transformation and tumorigenesis. Given the important roles of the small ubiquitin-related modifier (SUMO) pathway in controll...

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation.

Burkholderia cenocepacia is an opportunistic pathogen of the cystic fibrosis lung that elicits a strong inflammatory response. B. cenocepacia employs a type VI secretion system (T6SS) to survive in macrophages by disarming Rho-type GTPases, causing actin cytoskeletal defects. Here, we identified TecA, a non-VgrG T6SS effector responsible for actin disruption. TecA and other bacterial homologs b...

Learning Word Sense Distributions, Detecting Unattested Senses and Identifying Novel Senses Using Topic Models

Unsupervised word sense disambiguation (WSD) methods are an attractive approach to all-words WSD due to their non-reliance on expensive annotated data. Unsupervised estimates of sense frequency have been shown to be very useful for WSD due to the skewed nature of word sense distributions. This paper presents a fully unsupervised topic modelling-based approach to sense frequency estimation, whic...

Different Senses Visualization with Latent Semantic Analysis

Some psycholinguistic based algorithms have been proposed to emulate the management of the context that humans do, in the assumption that the value of a word is evanescent and take sense when interact with other structures. For example, predication algorithm (Kintsch, 2001), uses the vector representation of the words that produce LSA (Latent Semantic Analysis) to dynamically simulate the compr...